4′-((1R,2S)-2-Aminocyclopropyl)-[1,1′-biphenyl]-3-ol hydrochloride

产品名称：

1357299-45-6
OG-L002 hydrochloride
4′-((1R,2S)-2-Aminocyclopropyl)-[1,1′-biphenyl]-3-ol hydrochloride

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

OG-L002 is a recently developed inhibitor with IC₅₀ of 20 nM at LSD1 and much lower activity at MAO-A and MAO-B (1.38 and 0.72 μM, respectively). OG-L002 exhibits potent anti-viral activity in vitro and in mouse models of HSV infection. Lysine specific demethylase 1 (LSD1) is a histone demethylase that removes methyl groups from lysine 4 or 9 of H3 histone tails. Inhibition of LSD1 leds to suppression of herpes simplex and herpes zoster viral infections and viral reactivation from latency. MAO inhibitors (pargyline, tranylcypromine) are known to inhibit LSD1, but with low potency and selectivity. OG-L002 is a more selective and potent tool for LSD1 inhibition.

基本信息

经验(实验)分子式	C₁₅H₁₅NO · HCl
分子量	261.75
PubChem化学物质编号	329825831
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	, light yellow to dark orange
溶解性	DMSO: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	N[C@@H]1[C@@H](C(C=C2)=CC=C2C3=CC=CC(O)=C3)C1.Cl
InChI	1S/C15H15NO.ClH/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12;/h1-8,14-15,17H,9,16H2;1H/t14-,15+;/m1./s1
InChI key	LPVCAMIPTMRRLZ-LIOBNPLQSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable