PF-562,271

产品名称：

939791-38-5
PF-562,271
PF-00562271
N-(3-(((2-((2,3-Dihydro-2-oxo-1H-indol-5-yl)amino)-5- (trifluoromethyl)-4-pyrimidinyl)amino)methyl)-2-pyridinyl)-N-methyl-methanesulfonamide benzenesulfonate
PF 562271
PF-562271

产品介绍：

产品说明

应用

PF-562,271 has been used as a focal adhesion kinase (FAK) inhibitor to study its effects on the S100A9-induced tumor cell invasion in prostate cancer cell lines. It has also been used to study its effects on syndecan-1 (SDC-1) knockdown-induced upregulation of early growth regulator 1 (EGR1) in colon cancer cells.

生化/生理作用

PF-562,271 is a potent, ATP-competitive, reversible and selective inhibitor of FAK and Pyk2. PF-562,271 inhibits FAK phosphorylation in vivo.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₂₁H₂₀F₃N₇O₃S · C₆H₆O₃S
分子量	665.66
MDL编号	MFCD14105612
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	white to brown
溶解性	DMSO: 2 mg/mL, clear
创始人	Pfizer
储存温度	2-8℃
SMILES string	CN(S(=O)(C)=O)C1=NC=CC=C1CNC2=C(C(F)(F)F)C=NC(NC3=CC4=C(C=C3)NC(C4)=O)=N2.O=S(C5=CC=CC=C5)(O)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable