PF-3644022 水合物

产品名称：

PF-3644022 hydrate
(10R)-9,10,11,12-tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5′,6′:4,5]thieno[3,2-f]quinolin-8-one hydrate
PF-3644022 水合物

产品介绍：

产品说明

应用

PF-3644022 hydrate has been used for the inhibition of mitogen-activated protein kinase 2 (MK2) in human osteosarcoma cells (U2OS) and in colorectal carcinoma cells (CT26).

包装

5, 25 mg in glass bottle

生化/生理作用

PF-3644022 is a potent inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MK2; Ki = 3 nM). PF-3644022 inhibits TNFa and IL-6 production in LPS-stimulated human whole blood (IC₅₀ = 1.6 and 10.3 μM, respectively) and blocks TNFα production and paw swelling in a streptococcal cell wall-induced arthritis in rats.

特点和优势

This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

其他说明

PF3644022 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF3644022 probe summary on the Chemical Probes Portal website.
This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₂₁H₁₈N₄OS · xH₂O
分子量	374.46 (anhydrous basis)
MDL编号	MFCD21363374
PubChem化学物质编号	329823762
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	yellow to orange
溶解性	DMSO: ≥15 mg/mL
创始人	Pfizer
储存温度	2-8℃
SMILES string	O.C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c5ccc(C)nc5)C(=O)N1
InChI	1S/C21H18N4OS.H2O/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19;/h3-8,10,12,23H,9H2,1-2H3,(H,24,26);1H2/t12-;/m1./s1
InChI key	WHVUIWUUCVXAGR-UTONKHPSSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H319
预防措施声明	P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable