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位置:首页 > 品牌 > Sigma-Aldrich > (S)-2-(4′-Bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid hydrate

PD166793 hydrate

品牌
Sigma-Aldrich
货号
P0047
规格纯度
≥98% (HPLC)
参考价格
1649.92 *本价格含增值税费
促销
服务
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数量
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产品名称:
PD166793 hydrate
(S)-2-(4′-Bromo-biphenyl-4-sulfonylamino)-3-methyl-butyric acid hydrate
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

PD166793 is a broad spectrum, but class-selective, MMP inhibitor (low nM at MMP-2 & 3 and low μM at MMP-1, 7 & 9). Adding PD166793 to the high-fat diet substantially reduced the rise in blood glucose. The improvement of glucose homeostasis in PD166793-treated ZDF rats was a result of the enhancement of β-cell function. It prevents β-cell dysfunction and diabetes in female ZDF rats on a high-fat diet. It has been shown to block left ventricular remodeling and dysfunction in a rat model of heart failure. Preservation of normoglycemia and normal glucose tolerance in compound PD166793-treated animals is accompanied by preservation of the high serum insulin levels that are a consequence of the insulin resistance present in these animals. It is not reversing insulin resistance these animals. The most striking effect of the compound is on pancreatic insulin content and β-cell volume.

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C17H18BrNO4S · xH2O
分子量412.30 (anhydrous basis)
MDL编号MFCD12912437
PubChem化学物质编号329819997
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
创始人Pfizer
储存温度2-8℃
SMILES stringO.CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c2ccc(Br)cc2)C(O)=O
InChI1S/C17H18BrNO4S.H2O/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12;/h3-11,16,19H,1-2H3,(H,20,21);1H2/t16-;/m0./s1
InChI keyLUKRECOTGXWIDO-NTISSMGPSA-N
Gene Information

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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