Peretinoin

产品名称：

81485-25-8
Peretinoin
(2E,4E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,4,6,10,14-pentaenoic acid
E-5166
NIK-333
ACR
3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid
Acyclic retinoid
Polyprenoic acid
all-trans-3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid
K 333
NIK 333
E 5166
K333
E5166
K-333
NIK333
4,5-Didehydrogeranyl geranoic acid

产品介绍：

产品说明

生化/生理作用

Peretinoin is an orally active synthetic acyclic retinoid (ACR) whose in vivo anti-hepatocellular carcinoma (HCC) efficacy is attributed to its upregulatory activity toward retinoid nuclear receptors (RARbeta & RXRalpha), as well as negative regulation against sphingosine kinase 1 (SPHK1) expression and, thereby, sphingosine metabolic pathway. Peretinoin inhibits the replication of hepatitis B & C viruses in cultures (HBV & HCV EC₅₀ = 9-25 μM) and shows in vivo efficacy in rodent models of hepatocarcinogenesis among rats (10, 40, or 80 mg/kg/day p.o.) and mice (0.03% or 0.06% in diet) subjected to chronic inflammation induction by diethylnitrosamine (DEN).

基本信息

经验(实验)分子式	C₂₀H₃₀O₂
分子量	302.45
MDL编号	MFCD01742209

产品性质

测定	≥97% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable