PP121

产品名称：

1092788-83-4
PP121
1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 is the first inhibitor active on both Tyrosine kinases and the phosphatidylinositol-3-OH kinase (PI(3)K) family. The inhibitor is not effecting other serine-threonine protein kinases.
PP121 blocks the vascular endothelial growth factor (VEGF) receptor and its related signaling events. It also inhibits tumor cell proliferation by targeting oncogenic tyrosine kinase and phosphoinositide 3-kinases (PI3Ks).

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₇H₁₇N₇
分子量	319.36
MDL编号	MFCD12912434
PubChem化学物质编号	329819987
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	off-white
溶解性	DMSO: >10 mg/mL
储存温度	2-8℃
SMILES string	Nc1ncnc2n(nc(-c3cnc4[nH]ccc4c3)c12)C5CCCC5
InChI	1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)
InChI key	NVRXTLZYXZNATH-UHFFFAOYSA-N

安全信息

储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable