PF-06465469

产品名称：

1407966-77-1
PF-06465469
3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

PF-06465469 is a potent, covalent inhibitor of the nonreceptor tyrosine kinase Itk (IL-2 inducible T-cell kinase), which is expressed primarily in immune cells, and is strongly upregulated following activation of T-cells. PF-06465469 inhibits Itk enzymatic activity with an IC₅₀ of 2 nM. The compound blocks anti-CD3 induced phosphorylation of PLCg in Jurkat cells (IC₅₀ = 31 nM) and IL-2 production in anti-CD3 stimulated human whole blood (IC₅₀ = 48 nM).

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₃₀H₃₃N₇O₂
分子量	523.63
NACRES	NA.77

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear
创始人	Pfizer
储存温度	2-8℃

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335
预防措施声明	P302 + P352 - P305 + P351 + P338
危险分类	Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable