Rivaroxaban

产品名称：

366789-02-8
Rivaroxaban
BAY-59-7939
(S)-5-Chloro-N-{[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl} thiophene-2-carboxamide
BAY59-7939
5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide
5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
(S)-Rivaroxaban
BAY 59-7939

产品介绍：

产品说明

生化/生理作用

Rivaroxaban is an orally active, active site-targeting, highly potent and selective factor Xa (FXa) inhibitor (IC₅₀ = 0.7 nM; no activity against thrombin, trypsin, plasmin, FVIIa, FIXa, FXIa, urokinase, or activated protein C up to 20 μM) with good anticoagulant activity in vitro (dose for doubling fibrin formation time = 230/300 nM in human/rat plasma) and antithrombotic efficacy in vivo (ED₅₀ = 1 mg/kg i.v. or 5 mg/kg p.o. by rat arteriovenous shunt model).

基本信息

经验(实验)分子式	C₁₉H₁₈ClN₃O₅S
分子量	435.88
MDL编号	MFCD11974010

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
旋光性	[α]/D -34 to -44, c = 0.3 in DMSO
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃

安全信息

象形图
危险声明	H411
预防措施声明	P273 - P391 - P501
危险分类	Aquatic Chronic 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable