产品说明
生化/生理作用
PKUMDL-WQ-2201 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) that selectively inhibits serine synthesis in cancer cells. PKUMDL-WQ-2201 binds to allosteric site II, which is located in the substrate-binding domain. PKUMDL-WQ-2201 inhibits tumor growth of MDA-MB-468 xenografts in mice.
基本信息
| 经验(实验)分子式 | C15H14ClN3O3S |
| 分子量 | 351.81 |
产品性质
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to brown |
| 溶解性 | DMSO: 15 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | O=C(C(C=CC(C1=CC=C(C=NNC(NCC)=S)O1)=C2)=C2Cl)O |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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