4-(3′-(3″,5″-Dimethylphenyl)ureido)phenyl sulfamate

产品名称：

1330061-67-0
S4
4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamic acid ester
4-[(3,5-Dimethylphenyl)ureido]phenyl sulfamate
4-(3′-(3″,5″-Dimethylphenyl)ureido)phenyl sulfamate

产品介绍：

产品说明

生化/生理作用

S4 is a potent and selective inhibitor against sulfamate carbonic anhydrase (CA) subtypes CAIX & CAXII (Ki = 2, 7, 546, 5600 nM against human CA XII, IX, II, and I, respectively). S4 selectively inhibits migration upon anoxia/hypoxia-induced CAIX expression in cancer cultures (% inhibition/conc./cell line = 54%/100 μM/WRO, 65%/33 μM/MDA-MB-231), while exhibiting no inhibitory effects under normoxia or among non-CAIX-expressing cells (HCT116 & RT112). Daily intraperitoneal injection (10 mg/kg) is reported to reduce the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors in vivo.

基本信息

经验(实验)分子式	C₁₅H₁₇N₃O₄S
分子量	335.38
MDL编号	MFCD30182321
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
运输	ambient
储存温度	2-8℃
SMILES string	O=S(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(N)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable