SKA-121

产品名称：

1820708-73-3
SKA-121
5-Methylnaphth[2,1-d]oxazol-2-amine
SKA121
5-Methylnaphtho[2,1-d]oxazol-2-amine
SKA 121

产品介绍：

产品说明

生化/生理作用

SKA-121 is a KCa3.1 (IKCa1, IK1, KCa4, SKCa4, SK4) subtype-selective small conductance Ca2+-activated K+ channel (SK channel) positive-gating modulator (EC50 = 109 nM/KCa3.1 vs. 8.7 μM/KCa2.1, 6.8 μM/KCa2.2, 4.4 μM/KCa2.3) with 200- to 400-fold selectivity over CaV1.2 as well as representative KVs (KV1.3, KV2.1, KV3.1, and KV11.1) and NaV (NaV1.2, NaV1.4, NaV1.5, and NaV1.7) channels. When applied in vivo, SKA-121 significantly lowers mean arterial blood pressure in wild-type, but not KCa3.1(-/-), normotensive and hypertensive mice (100 mg/kg i.p.). SKA-121 is a more potent and selective KCa3.1 activator than SKA-31 (EC50 = 260 nM/KCa3.1, 2.9 μM/KCa2.1, 1.9 μM/KCa2.2, 2.9 μM/KCa2.3).

基本信息

经验(实验)分子式	C₁₂H₁₀N₂O
分子量	198.22

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	brown to dark gray
溶解性	DMSO: 2 mg/mL, clear
储存温度	2-8℃
SMILES string	CC(C1=C2C=CC=C1)=CC3=C2OC(N)=N3

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable