产品说明
应用
Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.
包装
5, 25 mg in glass bottle
生化/生理作用
Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells and reduces tumor burden in adenomatous polyposis patients.
其他说明
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. S3131.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
基本信息
| 经验(实验)分子式 | C20H17FO2S |
| 分子量 | 340.41 |
| EC 号 | 250-892-2 |
| MDL编号 | MFCD00869764 |
| PubChem化学物质编号 | 24899543 |
| NACRES | NA.77 |
产品性质
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 颜色 | yellow |
| 溶解性 | DMSO: ≥22 mg/mL |
| SMILES string | [H]\C(c1ccc(SC)cc1)=C2/C(C)=C(CC(O)=O)c3cc(F)ccc23 |
| InChI | 1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- |
| InChI key | LFWHFZJPXXOYNR-MFOYZWKCSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H302 - H317 - H334 - H361 |
| 预防措施声明 | P201 - P280 - P301 + P312 + P330 - P302 + P352 - P308 + P313 |
| 危险分类 | Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
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