产品说明
一般描述
Sphinganine (d17:0), also referred to as dihydrosphingosine, is devoid of double bond. Decarboxylating condensation of serine with palmitoyl-CoA yield keto intermediate(2-oxosphinganine), which is then reduced by NADPH to form Sphinganine.
应用
Sphinganine (d17:0) has been used in liquid chromatography-mass spectrometry (LC-MS) for the in-situ estimation of dihydrosphingosine utilization in N-(4-hydroxyphenyl)retinamide (4-HPR) resistant leukemia cells. It is suitable for use as an internal standard in metabolomic study.
生化/生理作用
Sphinganine (SPA) or D-erythro-sphinganine is involved in sphingolipid biosynthesis pathway. It acts as a precursor for ceramide. SPA has an ability to inhibit the activity of protein kinase c. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.
包装
5 mL Amber Glass Screw Cap Vial (860654P-5mg)
5 mL Amber Glass Screw Cap Vial (860654P-10mg)
基本信息
| 经验(实验)分子式 | C17H37NO2 |
| 分子量 | 287.48 |
| NACRES | NA.25 |
产品性质
| 形式 | powder |
| 包装 | pkg of 1 × 10 mg (860654P-10mg) pkg of 1 × 5 mg (860654P-5mg) |
| manufacturer/tradename | Avanti Polar Lipids 860654P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCC |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
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