SPP86

产品名称：

1357349-91-7
SPP86
1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC₅₀ value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 μM in a cell line expressing oncogenic RET and inhibited RET-induced ERα phosphorylation and proliferation in MCF7 cells with an IC₅₀ value of 1.0 μM, similar to tamoxifen.

基本信息

经验(实验)分子式	C₁₆H₁₅N₅
分子量	277.32
MDL编号	MFCD23379049
PubChem化学物质编号	329825875
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 10 mg/mL, clear
储存温度	2-8℃
SMILES string	NC1=NC=NC2=C1C(C#CC3=CC=CC=C3)=NN2C(C)C
InChI	1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19)
InChI key	JQOIRTDBHMDWMT-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable