4′-[[5-[[[(1S)-1-[4-(1,1-Dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]-[1,1′-biphenyl]-2-carboxylic acid

产品名称：

1415252-61-7
SR2595
4′-[[5-[[[(1S)-1-[4-(1,1-Dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]-[1,1′-biphenyl]-2-carboxylic acid
(S)-4′-((5-((1-(4-(tert-butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1′-biphenyl]-2-carboxylic acid

产品介绍：

产品说明

生化/生理作用

SR2595 is an inverse agonist of PPARG (PPARγ) with an IC50 value of 30 nM. It was found to promote osteogenic differentiation of isolated bone marrow-derived mesenchymal stem cells accompanied by increased expression of bone morphogenetic proteins BMP2 and BMP6. SR2595 showed good pharmacokinetics and can be administered orally. It caused no significant change in insulin sensitivity, fasting insulin levels, food consumption or body weight when administered orally to mice.

基本信息

经验(实验)分子式	C₃₇H₃₈N₂O₃
分子量	558.71
NACRES	NA.77

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	white to faint brown
溶解性	DMSO: 2 mg/mL, clear
运输	wet ice
储存温度	−20℃
SMILES string	O=C(C(C=C1)=CC2=C1N(C(C)=C2C)CC(C=C3)=CC=C3C4=C(C(O)=O)C=CC=C4)N[C@H](C(C=C5)=CC=C5C(C)(C)C)C

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable