UA62784

产品名称：

313367-92-9
UA62784
4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.

制备说明

UA62784 is soluble in DMSO at a concentration >2 mg/ml.

基本信息

经验(实验)分子式	C₂₃H₁₅NO₃
分子量	353.37
MDL编号	MFCD00489199
PubChem化学物质编号	329827627
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	yellow
溶解性	DMSO: >2 mg/mL
储存温度	2-8℃
SMILES string	COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
InChI	1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
InChI key	SVICLWPFAQYZLX-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
闪点(F)	Not applicable
闪点(C)	Not applicable