VU0453379 hydrochloride

产品名称：

1638646-27-1
VU0453379 hydrochloride
(S)2-CyclopentylN((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro1Hpyrrido[3,4b]indole-4-carboxamide hydrochloride

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC₅₀ = 1.3 μ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson′s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg.

基本信息

经验(实验)分子式	C₂₆H₃₄N₄O₂ · HCl
分子量	471.03
MDL编号	MFCD28987471
PubChem化学物质编号	329825812

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	H₂O: 20 mg/mL, clear
储存温度	2-8℃
SMILES string	CN1C2=C(C(C(NC[C@@H]3CCCN3C(C)C)=O)=CN(C4CCCC4)C2=O)C5=CC=CC=C51.Cl
InChI	1S/C26H34N4O2.ClH/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3;/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31);1H/t19-;/m0./s1
InChI key	OCMGNMGYQPPMFF-FYZYNONXSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable