产品说明
应用
JW74 has also been used to test its efficacy in concurrent radiation and cisplatin (CDDP)-mediated cytotoxicity using HeLa and cervical carcinoma SiHa cell lines. It has been used to modulate the level of β-catenin in chicken primordial germ cells (PGCs) in vitro.
JW74 has been used to modulate the level of β-catenin in chicken primordial germ cells (PGCs) in vitro.
包装
5, 25 mg in glass bottle
生化/生理作用
JW74 is a tankyrase inhibitor of β-catenin-mediated Wnt signaling activity. It degrades β-catenin by stabilizing axis inhibition protein (AXIN), a component of the β-catenin degradation complex. It reduces cell cycle progression and induces caspase-3 mediated cell apoptosis in osteosarcoma cells.
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo. It appears that JW74 affects the multiprotein complex consisting of b-catenin/GSK-3b/AXIN/APC /CK1 that controls the degradation of b-catenin. JW74 reduces growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S phase. JW74 also inhibits tumor formation and growth in the small intestine and colon of ApcMin mice.
基本信息
| 经验(实验)分子式 | C24H20N6O2S |
| 分子量 | 456.52 |
| MDL编号 | MFCD07048962 |
| PubChem化学物质编号 | 329825245 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: ≥20 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | COc1ccc(cc1)-n2c(SCc3nc(no3)-c4ccc(C)cc4)nnc2-c5ccncc5 |
| InChI | 1S/C24H20N6O2S/c1-16-3-5-17(6-4-16)22-26-21(32-29-22)15-33-24-28-27-23(18-11-13-25-14-12-18)30(24)19-7-9-20(31-2)10-8-19/h3-14H,15H2,1-2H3 |
| InChI key | KRIKILRRJCIWNB-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
m.cnreagent.com
