产品说明
应用
SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.
SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).
包装
5, 25 mg in glass bottle
生化/生理作用
SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.
基本信息
经验(实验)分子式 | C16H12F3N3S |
分子量 | 335.35 |
MDL编号 | MFCD06411432 |
PubChem化学物质编号 | 329824537 |
NACRES | NA.77 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | solid |
储存条件 | desiccated protect from light |
颜色 | white to off-white |
mp | 127-128.2 ℃ |
溶解性 | DMSO: >10 mg/mL H2O: insoluble |
储存温度 | 2-8℃ |
SMILES string | N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F |
InChI | 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+ |
InChI key | JLOXTZFYJNCPIS-FYWRMAATSA-N |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich