SMER28

产品名称：

307538-42-7
SMER28
6-Bromo-N-2-propenyl-4-quinazolinamine

产品介绍：

产品说明

应用

SMER28 may be used in mTOR-mediated signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

基本信息

经验(实验)分子式	C₁₁H₁₀BrN₃
分子量	264.12
MDL编号	MFCD02166825
PubChem化学物质编号	329824598
NACRES	NA.77

产品性质

质量水平	100
测定	>99% (HPLC)
形式	solid
溶解性	DMSO: >20 mg/mL H₂O: insoluble
储存温度	2-8℃
SMILES string	Brc1ccc2ncnc(NCC=C)c2c1
InChI	1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
InChI key	BCPOLXUSCUFDGE-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves