CYM-5541

产品名称：

945128-26-7
CYM-5541
ML249
CYM5541
N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC₅₀ of between 72 and 132 nM compared to S1P1 EC₅₀ > 10 μM, S1P2 EC₅₀> 50 μM, S1P4 EC₅₀ > 50 μM, and S1P5 EC₅₀ > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.

特点和优势

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₉H₂₈N₂O₂
分子量	316.44
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear (warmed)
储存温度	2-8℃

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable