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位置:首页 > 品牌 > Sigma-Aldrich > (+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione

Sorbinil

(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione

品牌
Sigma-Aldrich
CAS
68367-52-2
货号
S7701
规格纯度
≥98% (HPLC)
参考价格
1682.59 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
68367-52-2
Sorbinil
CP 45634
(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione
(4S)-6-Fluoro-2,3-dihydro-spiro[4H-1-benzopyran-4,4′-imidazolidine]-2′,5′-dione
产品介绍:

产品说明

应用

Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
Sorbinil may be used in cell signaling and neuroscience studies.

包装

5, 25 mg in glass bottle

生化/生理作用

Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.
Sorbinil is an inhibitor of Aldose Reductase (AR). AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer.

特点和优势

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C11H9FN2O3
分子量236.20
MDL编号MFCD00867380
PubChem化学物质编号329824587
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D +50 to +60°, c = 1 in methanol
颜色 white to off-white
溶解性DMSO: ≥20 mg/mL
创始人Pfizer
储存温度2-8℃
SMILES stringFc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1
InChI1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
InChI keyLXANPKRCLVQAOG-NSHDSACASA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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