CyPPA

产品名称：

73029-73-9
CyPPA
Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine

产品介绍：

产品说明

应用

CyPPA has been used:

to test its inhibitory functionality on melanogenesis
as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells

包装

5, 25 mg in glass bottle

生化/生理作用

CyPPA is a positive modulator of small conductance Ca²⁺-activated K⁺ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC₅₀ of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.

特点和优势

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C₁₆H₂₃N₅
分子量	285.39
MDL编号	MFCD01550586
PubChem化学物质编号	329775087
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	white
溶解性	DMSO: >10 mg/mL H₂O: <2 mg/mL
储存温度	2-8℃
SMILES string	Cc1cc(NC2CCCCC2)nc(n1)-n3nc(C)cc3C
InChI	1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)
InChI key	USEMRPYUFJNFQN-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335 - H413
预防措施声明	P273 - P302 + P352 - P305 + P351 + P338
危险分类	Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves