6,8-Bis(benzylthio)-octanoic acid

产品名称：

95809-78-2
6,8-Bis(benzylthio)-octanoic acid
6,8-Bis[(phenylmethyl)thio-octanoic acid
CPI-613

产品介绍：

产品说明

应用

6,8-Bis(benzylthio)-octanoic acid has been used as pyruvate dehydrogenase (PDH) inhibitor:

to study its effects on neurite outgrowth in primary mouse dorsal root ganglia cells
to induce α-smooth muscle actin (αSMA) and pro-collagen I expression and to assess PDH enzyme activity in whole-cell lysates
to validate basal respiration in tissue respirometry

包装

5, 25 mg in glass bottle

生化/生理作用

6,8-Bis(benzylthio)-octanoic acid (CPI-613) is a lipoate analog. It acts as a mitochondrial disrupter by blocking the mitochondrial enzymes pyruvate dehydrogenase and α-ketoglutarate dehydrogenase.
6,8-Bis(benzylthio)-octanoic acid is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. 6,8-Bis(benzylthio)-octanoic acid has been granted orphan drug status by the US FDA for pancreatic cancer.

其他说明

Air Sensitive

基本信息

经验(实验)分子式	C₂₂H₂₈O₂S₂
分子量	388.59
MDL编号	MFCD22420826
PubChem化学物质编号	329825400
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 15 mg/mL (clear solution)
储存温度	2-8℃
SMILES string	OC(=O)CCCCC(CCSCc1ccccc1)SCc2ccccc2
InChI	1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24)
InChI key	ZYRLHJIMTROTBO-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H410
预防措施声明	P273 - P501
危险分类	Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable