N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea

产品名称：

501925-31-1
PNU-120596
N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea
NSC 216666

产品介绍：

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₁₃H₁₄ClN₃O₄
分子量	311.72
MDL编号	MFCD00095313
PubChem化学物质编号	329819995
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
颜色	white to off-white
溶解性	DMSO: >10 mg/mL
创始人	Pfizer
储存温度	room temp
SMILES string	O=C(NC1=NOC(C)=C1)NC2=CC(Cl)=C(OC)C=C2OC
InChI	1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
InChI key	CEIIEALEIHQDBX-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable