5,7-二羟基-2-（4-羟基苯基）-4-苯并吡喃酮

产品名称：

520-36-5
Apigenin
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
4′,5,7-Trihydroxyflavone
芹菜素
4 ′,5,7-三羟基黄酮
5,7-二羟基-2-（4-羟基苯基）-4-苯并吡喃酮

产品介绍：

产品说明

一般描述

Apigenin (ApI) is also called as 5,7,4′-trihydroxyflavone. It is a natural compound, found in several fruits and herbs, like, oranges, onions and parsley.

包装

5 mg in glass bottle
25, 100 mg in poly bottle

生化/生理作用

Apigenin (ApI) blocks the development of thyroid cancer cells by attenuating epidermal growth factor receptor (EGF-R) tyrosine phosphorylation and phosphorylation of ERK mitogen-activated protein (MAP) kinase. Apigenin participates in the modulation of different signaling cascades. It possesses several functions such as, antiapoptosis, anti-inflammation, anticancer, antibacterial and antioxidant effects.
一种植物类黄酮，研究发现它通过在G₂/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

基本信息

经验(实验)分子式	C₁₅H₁₀O₅
分子量	270.24
Beilstein	262620
EC 号	208-292-3
MDL编号	MFCD00006831
NACRES	NA.79

产品性质

质量水平	200
测定	≥97% (TLC)
形式	powder
mp	>300 ℃ (lit.)
溶解性	DMSO: 27 mg/mL 1 M KOH: 50 mg/mL
储存温度	−20℃
SMILES string	Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChI key	KZNIFHPLKGYRTM-UHFFFAOYSA-N
Gene Information	human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931) mouse ... Hexa(15211) rat ... Adora1(29290), Adora2a(25369), IL4(287287), Tnf(24835)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3