N,N,N,N′,N′,N′-Hexamethyl-1,6-hexanediaminium dichloride

产品名称：

60-25-3
Hexamethonium chloride
Hexamethonium dichloride
N,N,N,N′,N′,N′-Hexamethyl-1,6-hexanediaminium dichloride
N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dichloride

产品介绍：

产品说明

一般描述

Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction.

应用

Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons.

包装

5, 25 g in poly bottle

生化/生理作用

Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR.

基本信息

线性分子式	(CH₃)₃N(Cl)(CH₂)₆N(Cl)(CH₃)₃
分子量	273.29
Beilstein	3714806
EC 号	200-465-1
MDL编号	MFCD00031563
PubChem化学物质编号	24277842
NACRES	NA.77

产品性质

形式	solid (hygroscopic)
颜色	white
溶解性	H₂O: soluble ethanol: soluble
SMILES string	[Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C
InChI	1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
InChI key	PYIHTIJNCRKDBV-UHFFFAOYSA-L
Gene Information	human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)