伊潘立酮(Iloperidone)

产品名称：

133454-47-4
Iloperidone
Zomaril
1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
伊潘立酮(Iloperidone)

产品介绍：

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki < 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki < 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki < 10 nM) which may contribute to the drug′s efficacy on mood and cognition.

基本信息

经验(实验)分子式	C₂₄H₂₇FN₂O₄
分子量	426.48
MDL编号	MFCD00866688
PubChem化学物质编号	329825945
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 5 mg/mL, clear
储存温度	−20℃
InChI	1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
InChI key	XMXHEBAFVSFQEX-UHFFFAOYSA-N
Gene Information	human ... DRD2(1813), HTR2A(3356)

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H413
预防措施声明	P273 - P301 + P310 + P330
危险分类	Acute Tox. 3 Oral - Aquatic Chronic 4
储存分类代码	6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable