(<I>R</I>)-N-Methyl-γ-(2-methyl-phenoxy)benzenepropanamine hydrochloride

产品名称：

82248-59-7
(R)-Tomoxetine hydrochloride
Atomoxetine Hydrochloride
(R)-N-Methyl-γ-(2-methyl-phenoxy)benzenepropanamine hydrochloride

产品介绍：

产品说明

应用

(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:

to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice
to study its effects on set shifting in rats
to study its effects on rat brain as a result of its long-term use

包装

25, 50, 100 mg in glass bottle

生化/生理作用

(R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters. It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC). (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter. It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).
Norepinephrine uptake blocker.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₁₇H₂₁NO · HCl
分子量	291.82
MDL编号	MFCD06410992
PubChem化学物质编号	24278760
NACRES	NA.77

产品性质

质量水平	100
形式	solid
创始人	Eli Lilly
储存温度	2-8℃
SMILES string	CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl
InChI	1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1
InChI key	LUCXVPAZUDVVBT-UNTBIKODSA-N
Gene Information	human ... SLC6A2(6530)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)