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Tasimelteon

他司美琼

品牌
Sigma-Aldrich
CAS
609799-22-6
货号
SML2030
规格纯度
≥98% (HPLC)
参考价格
1202.81 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
609799-22-6
Tasimelteon
VEC-162
BMS-214778
Hetlioz
MA 1
(1R, 2R)-N-[2- (2,3-Dihydrobenzofuran-4-yl)cyclopropylmethyl]propanamide
N-[[(1R,2R)-2-(2,3-Dihydro-4-benzofuranyl)cyclopropyl]methyl]propanamide
他司美琼
产品介绍:

产品说明

生化/生理作用

Tasimelteon is a Dual Melatonin Receptor Agonist (DMRA) recently approved (Hetlioz) for the treatment of Non-24-hour sleep–wake disorder, a disorder primarily found in the totally blind, where a lack of normal synchronization between the 24-hour light–dark cycle and the endogenous circadian rhythm causes it to drift out of alignment with conventional sleep–wake schedules. The endogenous rhythm of the circadian pacemaker in the suprachiasmatic nuclei (SCN) is typically slightly longer than 24 h and therefore must be synchronized to the 24-hour day, normally by light, but exogenous melatonin can also phase-shift circadian rhythms. Tasimelteon is a selective agonist for the SCN melatonin receptors MT1 and MT2 with greater affinity for the MT2 receptor thought to be more important in mediating circadian rhythm phase-shifting. EC50 values are 0.75 nM for MT1 and 0.1 nM for MT2 measured by inhibition of forskolin-stimulated cAMP accumulation in NIH-3T3 cells expressing human MT1 and MT2.

基本信息

经验(实验)分子式C15H19NO2
分子量245.32
MDL编号MFCD09033789

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(CC)NC[C@@H]1C[C@H]1C2=C3C(OCC3)=CC=C2

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H336 - H361
预防措施声明P201 - P308 + P313
危险分类Repr. 2 - STOT SE 3
靶器官Central nervous system
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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