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IgG from rat serum

IgG 来源于大鼠血清

品牌
Sigma-Aldrich
货号
I8015
规格纯度
technical grade, ≥80% (SDS-PAGE), buffered aqueous solution
参考价格
1295.91 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
IgG from rat serum
Rat IgG
IgG 来源于大鼠血清
大鼠 IgG
产品介绍:

产品说明

一般描述

IgG (immunoglobulin G) antibody is enriched in mother′s milk. IgG is a major class of immunoglobulin. It contributes to 10−20% of plasma protein and is regarded as one of the most abundant serum protein. It consists of four subclasses: IgG1, IgG2, IgG3 and IgG4. The IgG structure possesses four polypeptide chains containing two identical γ heavy (H) chains and two identical κ or λ light (L) chains of 50kDa and 25kDa respectively. The chains are interlinked with a disulfide bond. Both the L and the H chains consist of a variable domain at the N-terminal. The C-terminal bears′ constant domains: three in H chain with a hinge region and one in the L chain. The variable region of IgG antibody is specific to antigens and is highly conserved.

应用

IgG from rat serum has been used:

  • To block programmed death ligand 1.
  • As a control antibody to study the role of integrin b1 in spindle morphology
  • In FACS (flow cytometry) staining
  • ELISA (enzyme linked immunosorbent assay)


IgG from rat serum was used to block non-specific staining during FACS of peritoneal cells isolated from BALB/c mice. It was used as positive control in VDR staining of male and female breast tumor cells. IgG from rat serum was injected in control mice in tumor transplantation studies.

包装

10, 50, 100 mg in glass bottle

生化/生理作用

IgG antibody has its function similar to IgM antibody in complement system activation. IgG participates in hypersensitivity type II and type III. It helps in opsonization, complement fixation and antibody-dependent cell-mediated cytotoxicity.
IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.2, containing 15 mM sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00164131
NACRESNA.46

产品性质

质量水平200
偶联物unconjugated
等级technical grade
测定≥80% (SDS-PAGE)
形式buffered aqueous solution
运输dry ice
储存温度−20℃

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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