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Anti-Rab18 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200173
规格纯度
~1.0 mg/mL, affinity isolated antibody
参考价格
5045.46 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Rab18 antibody produced in rabbit
Anti-RAB18LI1
Anti-ras-related protein Rab-18
产品介绍:

产品说明

一般描述

Rab18 is a member of the Rab family of small guanosine triphosphatases (GTPases). The Rab family belongs to the Ras superfamily of small guanosine triphosphatases (GTPases). Rab proteins contain conserved regions involved in guanine-nucleotide binding, and hypervariable C-terminal domains with a cysteine motif.

应用

Anti-Rab18 antibody produced in rabbit has been used in:

  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

生化/生理作用

Rab guanosine triphosphatases (Rab GTPases) are central regulators of membrane trafficking between different subcellular compartments of eukaryotic cells. Their regulatory capacity depends on their ability to cycle between the guanosine diphosphate (GDP)-bound inactive and GTP-bound active states. Activation of a Rab protein is coupled to its association with intracellular membranes. Through their effector proteins, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement and membrane fusion. The conserved regions of Rab proteins are implicated in subcellular targeting. Each Rab protein shows a characteristic subcellular distribution. Therefore, antibodies to Rab proteins may serve as useful tool for studying subcellular localization and membrane organization. Rab18 is involved in retrograde Golgi-endoplasmic reticulum (ER) trafficking.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~23 kDa (an additional band at ∼43 kDa may appear in some extract preparations)
species reactivityrat, human, mouse
浓度~1.0 mg/mL
technique(s)immunoprecipitation (IP): 5-10 μg using lysates of human PC3 cells
indirect immunofluorescence: 2.5-5.0 μg/mL using rat NRK cells
western blot: 1-2 μg/mL using whole extracts of mouse MM3MG cells
UniProt登记号Q9NP72
运输dry ice
储存温度−20℃
Gene Informationhuman ... RAB18(22931)
mouse ... Rab18(19330)
rat ... Rab18(307039)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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