产品说明

一般描述

DC-SIGN is a type II protein C-type lectin that binds mannose-rich molecules such as ICAM-3 and ICAM-2 in a calcium dependent manner. DC-SIGN, a 44 kDa molecule, is identical to the HIV-1 binding protein.

特异性

Recognizes human DC-SIGN on transfected cells and on monocyte derived dentritic cells. The antibody does not react with either parental mouse cells or irrelevant transfectants, such as human DC-SIGN2.

免疫原

purified from NIH/3T3 cells transfected with recombinant human DC-SIGN.

应用

Monoclonal Anti-DC-SIGN1 antibody produced in mouse is suitable for flow cytometry, immunocytochemistry at a working concentration of 8-25 μg/mL, immunohistochemistry at 8-25 μg/mL using fixed cells and tissue sections and western blotting at 1 μg/mL.

生化/生理作用

DC-SIGN1 is involved in molecular interactions between dendritic cells and resting T-cells. DC-SIGN interacts with viruses such as X4, R5, X4R5 HIV-1 strains, HIV-2, and SIV. It captures HIV-1 through its interaction with the gp120 envelope glycoprotein and promotes efficient infection of CD4⁺ T cells that co-express chemokine receptors.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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