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Anti-VEGF-B Antibody

品牌
Sigma-Aldrich
货号
ABC429
规格纯度
1 mg/mL, from rabbit
参考价格
5854.74 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-VEGF-B Antibody
Vascular endothelial growth factor B, VEGF-B, VEGF-related factor, VRF
产品介绍:

产品说明

一般描述

VEGF-B, also known as Vascular endothelial growth factor B, VEGF-related factor, VRF, and encoded by the gene VEGFB/VRF, is an endothelial cell growth factor that has multiple splice variants and plays roles in angiogenesis but also in cardiac muscle function, coronary vascular development, chemotaxis of endothelial cells and mast cells, apoptosis regulation, platelet activation, cell division, wound healing and the activation of various signaling pathways. VEGFB is a secreted protein that stays associated with cells because of its ability to bind to heparin. VEGFB is expressed in all cells except for liver cells with the highest levels found in muscle and pancreatic cells. VEGFB levels in plasma are also being studied as a potential biomarker for ventricle damage after heart attacks. High levels of plasma VEGFB show little remodeling whereas patients with lower levels had significant ventricle remodeling, thus VEGFB may have clinical utility in the identification of patients at high risk of remodeling and therefore ventricle damage.

免疫原

Epitope: Unknown
KLH-conjugated linear peptide corresponding to human VEGF-B.

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected VEGF-B in human skeletal muscle myocytes and vascular tissue and cardiac myocytes in human heart.
Detect VEGF-B using this Anti-VEGF-B Antibody validated for use in western blotting & IHC (Paraffin).
Research Sub Category
Apoptosis - Additional
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in human skeletal muscle tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected VEGF-B in 10 µg of human skeletal muscle tissue lysate.

目标描述

~40/32/25 kDa observed. The ~40kDa band observed is likely due to homo and/or hetero-dimers, the ~32kDa band observed is likely due to glycosylation, and the ~25kDa band is un-modified VEGF186 (Olofsson, B., et al. (1998). Proc Natl Acad Sci USA. 95(20):11709-11714).

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman
浓度1 mg/mL
technique(s)immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号NP_003368
UniProt登记号P49765
运输wet ice
Gene Informationhuman ... VEGFB(7423)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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