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Anti-Nup98 antibody, Rat monoclonal

Monoclonal Anti-Nup98 大鼠抗

品牌
Sigma-Aldrich
货号
N1038
规格纯度
clone 2H10, purified from hybridoma cell culture
参考价格
4731.57 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Nup98 antibody, Rat monoclonal
Anti-Nucleoporin, 98-kD
Monoclonal Anti-Nup98 大鼠抗
产品介绍:

产品说明

一般描述

Monoclonal Anti-Nup98 (rat IgG2c- isotype) is derived from the hybridoma 2H10 produced by the fusion of mouse myeloma cells (SP2 cells) and splenocytes from WKY/NCrj rat immunized with a recombinant fragment of human Nup98. Nup96 and Nup98 are the nucleoporins that are formed by the cleavage of 186 kDa precursor protein.
Nucleoporin-98kDa (Nup98) is part of the nuclear pore complex. It possesses two domains and the gene encoding it is localized on human chromosome 11.

应用

Anti-Nup98 antibody, Rat monoclonal may be used in:

  • enzyme linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunocytochemistry

生化/生理作用

Nup98 functions as a docking protein for cytosol mediated docking of import substrates. Securin protein damage caused by the anaphase-promoting complex (APC) during mitosis, is regulated by the nucleocytoplasmic transport factors Rae1 and Nup98. In mice, collective haploinsufficiency of Rae1 and Nup98 gene causes premature separation of sister chromatids and severe aneuploidy. In addition, it also leads to untimely degradation of securin. Chromosome rearrangement between the HOXA9 (homeobox A9) gene and the nucleoporin gene Nup98 has been observed in some human myeloid leukemia patients.
Nucleoporin-98kDa (Nup98) is involved in the translocation of RNA and proteins across the nucleus. It is also a regulator of chromosomal segregation and gene expression. The protein also binds to other nucleoporins and is associated with acute myelogenous leukemia.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD09265425
NACRESNA.41

产品性质

质量水平200
生物来源rat
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆2H10, monoclonal
形式buffered aqueous solution
分子量antigen ~98 kDa
species reactivityhuman, rat
浓度~2 mg/mL
technique(s)immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 0.5-1 μg/mL using HeLa nuclear extract
同位素/亚型IgG2cκ
UniProt登记号P52948
运输dry ice
储存温度−20℃
Gene Informationhuman ... NUP98(4928)
rat ... Nup98(81738)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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