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Anti-BRD7 antibody, Rat monoclonal

品牌
Sigma-Aldrich
货号
SAB4200047
规格纯度
clone BRM 2D3, purified from hybridoma cell culture
参考价格
6296.93 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-BRD7 antibody, Rat monoclonal
Anti-BP75
Monoclonal Anti-BRD7 antibody produced in rat
Anti-NAG4
Anti-Bromodomain containing 7
Anti-CELTIX1
产品介绍:

产品说明

一般描述

Monoclonal Anti-BRD7 (rat IgG2a isotype) is derived from the hybridoma BRM 2D3 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from rat immunized with a fusion protein expressing a fragment of human BRD7. Bromodomain containing (BRD7) is a novel bromodomain gene.

应用

Monoclonal Anti-BRD7 antibody produced in rat has been used in several immunochemical techniques including

  • immunoblotting
  • immunoprecipitation
  • immunocytochemistry

生化/生理作用

Bromodomain containing (BRD7) inhibits cell growth and cell cycle progression by transcriptional regulation of some cell cycle-related genes as well as some important molecules involved in ras/mitogen-activated protein kinase(MEK)/extracellular-signal-regulated kinase (ERK) and retinoblastoma tumor suppressor protein (RB)/ E2 factor (E2F) pathways. Its transcriptional down regulation has been shown to be critical to the pathogenesis of nasopharyngeal carcinoma (NPC). Specifically, DNA methylation decreases the expression of BRD7 in NPC cells. Furthermore, DNA methylation of BRD7 promoter is increased in the tumor and in matched blood samples from NPC patients than in blood samples from healthy individuals. Therefore, it has been suggested that DNA methylation of BRD7 promoter might act as a potential diagnostic marker in NPC.

外形

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rat
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆BRM 2D3, monoclonal
形式buffered aqueous solution
分子量antigen ~80 kDa
species reactivityhuman, bovine, canine, monkey, rat, mouse
包装antibody small pack of 25 μL
technique(s)immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 0.5-1.0 μg/mL using HeLa cells extract
同位素/亚型IgG2a
UniProt登记号Q9NPI1
运输dry ice
储存温度−20℃
Gene Informationhuman ... BRD7(29117)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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