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Monoclonal Anti-ASPP1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
A4355
规格纯度
~2 mg/mL, clone LXO54.2, purified immunoglobulin, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
Monoclonal Anti-ASPP1 antibody produced in mouse
Anti-protein phosphatase 1 regulatory subunit 13B
Anti-PPP1R13B
Anti-Apoptosis-stimulating protein of p53, 1
产品介绍:

产品说明

一般描述

ASPP1 interacts with p53 to enhance p53-induced apoptosis.
Monoclonal Anti-ASPP1 (mouse IgG1 isotype) is derived from the hybridoma LXO54.2 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with a recombinant fragment of human ASPP1, amino acids. Apoptosis-stimulating protein of p53, 1 (ASPP1) belongs to the ASPP family of proteins. This protein contains a proline-rich region, four ankyrin repeats, and an SH3 domain in the C-terminal end.

免疫原

recombinant fragment of human ASPP1 (amino acids 1-308).

应用

Monoclonal Anti-ASPP1 antibody can be used for western blot at 1-2 μg/mL using total cell extract of human osteogenic sarcoma, U-2-OS. The antibody can also be used for microarray and immunoprecipitation assays.

生化/生理作用

Apoptosis-stimulating protein of p53, 1 (ASPP1) is known to stimulate RAS signalling which subsequently enhances p53-dependent apoptosis in cancer cells. Furthermore, ASPP1 can also induce p53-independent apoptosis by enhancing the apoptotic functions of p63 and p73. Monoclonal Anti-ASPP1 antibody recognizes human and mouse ASPP1.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD08705574
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆LXO54.2, monoclonal
形式buffered aqueous solution
分子量antigen ~175 kDa
species reactivityhuman, mouse
浓度~2 mg/mL
technique(s)immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1-2 μg/mL using total cell extract of human osteogenic sarcoma, U-2-OS
同位素/亚型IgG1
UniProt登记号Q96KQ4
运输dry ice
储存温度−20℃
Gene Informationhuman ... PPP1R13B(23368)
mouse ... Ppp1r13b(21981)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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