产品说明
一般描述
High mobility group A2 (HMGA2) protein is a non-histone architectural transcription factor. This protein belongs to the high-mobility group adenine/thymine (AT)-hook (HMGA) family. HMGA2 is expressed in the mesenchyme prior differentiation and tumors of epithelial origin. The HMGA2 gene is located on the human chromosome at 12q14.3.
免疫原
Recombinant fragment corresponding to a region within amino acids 1 and 109 of HMGA2 (Uniprot ID#P52926)
应用
Anti-HMGA2 antibody produced in rabbit has been used in immunohistochemistry (1:250), (1:100), (1:4000).
生化/生理作用
High mobility group A2 (HMGA2) protein is involved in regulating the activity of various genes by binding to the adenine/thymine (AT)-rich sequences present in the minor groove of B‑form DNA. This protein plays a role in many biological processes such as the DNA damage repair process, senescence, apoptosis, and cell cycle process. HMGA2 protein also plays a role in epithelial-mesenchymal transition and telomere restoration. Overexpression of HMG2A gene is observed in metastatic lung adenocarcinoma.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | liquid |
| 分子量 | 12 kDa |
| species reactivity | rat, human, mouse |
| 浓度 | 0.7 mg/mL |
| technique(s) | ChIP: suitable immunofluorescence: suitable immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable immunoprecipitation (IP): suitable western blot: 5000-50000 |
| UniProt登记号 | P52926 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... HMGA2(8091) |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H317 - H412 |
| 预防措施声明 | P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313 |
| 危险分类 | Aquatic Chronic 3 - Skin Sens. 1 |
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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