Monoclonal Anti-GABRB3 antibody produced in mouse

产品说明

一般描述

The γ-aminobutyric acid type A receptor β3 subunit (GABRB3) gene with nine exons spanning 250kb, is mapped to human chromosome 15q12, a hot region of genomic rearrangements. The gene codes for β3 subunit of GABAA receptor, which belongs to the GABA (γ-aminobutyric acid) receptor gene family.

特异性

Detects ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1.

免疫原

Fusion protein amino acids 370-433 of mouse GABA-A_r Beta3, Accession Number AAB60502.

生化/生理作用

γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity. Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia. GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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