Anti-phospho-TAK1 (Ser412) Antibody

产品说明

一般描述

TAK1 MAPKKK is activated by TAB1 to transform growth factor-beta (TGF-beta) signaling. TAK1 can also associate with TAB1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. TAK1 has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.

特异性

This antibody recognizes TAK1 phosphorylated at Ser412.

免疫原

KLH-conjugated linear peptide corresponding to human TAK1 phosphorylated at Ser412.
Epitope: Phosphorylated Ser412

应用

Detect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.

质量

Evaluated by Western Blot in lambda phosphatase treated and untreated Murine RAW cell lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected TAK1 on 10 µg of lambda phosphatase treated and untreated Murine RAW cell lysates.

目标描述

~70 kDa observed

外形

Affinity purified

分析说明

Control
Lambda phosphatase treated and untreated Murine RAW cell lysates

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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产品性质

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