Almotriptan Malate

产品名称：

181183-52-8
Almotriptan Malate
PNU 180638
3-[2-(Dimethylamino)ethyl]-5-(pyrrolidin-1-ylsulfonylmethyl )-1H-indole malate

产品介绍：

产品说明

应用

Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.
Almotriptan at an oral dose of 12.5 mg, is recommended to be safe for treating migraine.

生化/生理作用

Almotriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Almotriptan has low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower. Affinity for 5-HT(7) and 5-HT(1A) receptors was approximately 40 and 60 times lower than that for 5-HT(1B/1D) receptors, respectively.

基本信息

经验(实验)分子式	C₁₇H₂₅N₃O₂S · C₄H₆O₅
分子量	469.55
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	H₂O: 10 mg/mL, clear
储存温度	−20℃
InChI	1S/C17H25N3O2S.C4H6O5/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;5-2(4(8)9)1-3(6)7/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;2,5H,1H2,(H,6,7)(H,8,9)
InChI key	QHATUKWEVNMHRY-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable