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Anti-Chloride Channel CLC-5 (Clcn5) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
C1116
规格纯度
affinity isolated antibody, lyophilized powder
参考价格
3862.23 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
Anti-Chloride Channel CLC-5 (Clcn5) antibody produced in rabbit
产品介绍:

产品说明

免疫原

peptide corresponding to amino acid residues 401-415 of rat CLC5. Mouse sequence is identical; human sequence is 14/15 residues identical.

应用

Anti-Chloride Channel CLC-5 (Clcn5) antibody produced in rabbit is suitable for western blotting at a dilution of 1:200 using rat kidney membranes.

生化/生理作用

H(+)/Cl(-) exchange transporter 5 is a protein encoded by the CLCN5 gene in humans. It encodes a member of the CLC gene family of chloride ion channels and ion transporters. CLCN5 is highly expressed in endosomes of proximal tubule cells and is essential for endocytosis. Mutations in CLCN5 causes Dent′s disease leading to renal failure. It is also involved in low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis and renal failure. Majority of these disease-causing mutations in ClC-5 are misprocessed and retained in the ER (endoplasmic reticulum) and may alter intramolecular interactions within the full-length ClC-5 protein. CLC-5 plays a crucial role in the process of endocytosis in the proximal tubule of the kidney and mutations that alter protein function are the cause of Dent′s disease. It may act as an electrically shunting Cl- channel in early endosomes, facilitating intraluminal acidification.

外形

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.025% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD06798431
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
species reactivityhuman, mouse, rat
technique(s)western blot: 1:200 using rat kidney membranes
UniProt登记号P51795
运输dry ice
储存温度−20℃
Gene Informationhuman ... CLCN5(1184)
mouse ... Clcn5(12728)
rat ... Clcn5(25749)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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