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Anti-Caspr2 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
C8737
规格纯度
affinity isolated antibody, lyophilized powder
参考价格
4731.57 *本价格含增值税费
促销
服务
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数量
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产品名称:
Anti-Caspr2 antibody produced in rabbit
Anti-Contactin-Associated Protein 2
产品介绍:

产品说明

一般描述

CASPR2 (Contactin-associated protein-like 2) belongs to CASPR family and neurexin superfamily.

免疫原

peptide corresponding to amino acids residues 1315-1331 of human Caspr2.

应用

Anti-CASPR2 antibody has been used for immunohistochemitry and western blotting of proteins from mouse brain samples. It is also suitable for western blot analysis at a dilution of 1:1,000 by using rat brain membranes.

生化/生理作用

CASPR2 (Contactin-associated protein-like 2) associates shaker like K+ channels in the juxtaparanodal region flanking nodes of Ranvier. It is expressed in different and distinct regions of the central nervous system (CNS) where it may plays an important role in cell recognition. CASPR and CASPR2 may interact with the actin-based cytoskeleton through cytoskeleton-associated protein 4.1B. CASPR2 is crucial for synapse formation and outgrowth of axon and dendrite. CASPR2 forms a complex with G-protein-coupled receptor 37 (GPR37) and multiple PDZ domain protein 1 (MUPP1). Disruption of the complex is linked with autism spectrum disorder (ASD). Genetic variations in CASPR2 are also associated with intellectual disability, epilepsy, schizophrenia and language disorders. It also regulates diet-induced obesity.

外形

Lyophilized from 0.3 mg/ml in phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose, and ≤0.1% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD03791625
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
分子量antigen 180 kDa
species reactivityrat, mouse, human
technique(s)immunohistochemistry: suitable
western blot: 1:1,000 using rat brain membranes
UniProt登记号Q9UHC6
储存温度−20℃
Gene Informationhuman ... CNTNAP2(26047)
mouse ... Cntnap2(66797)
rat ... Cntnap2(362355)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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