Anti-CCL17/TARC antibody produced in goat

产品说明

一般描述

Chemokine (C-C motif) ligand 17 (CCL17) belonging to the CC chemokine family. It is also known as thymus and activation regulated chemokine (TARC), ABCD-2, SCYA17, A-152E5.3. It is expressed constitutively in thymus and transiently in stimulated peripheral blood mononuclear cells.

免疫原

purified, E. coli-derived, recombinant human CCL-17.

应用

Anti-CCL17/TARC antibody produced in goat is suitable for the following applications:

• Immunohistochemistry using formalin-fixed and paraffin-embedded sections at a concentration of 5-15μg/mL.
• Neutralization
• Western blotting at a concentration of 0.1-0.2μg/mL

生化/生理作用

Thymus and activation regulated chemokine (TARC) may play an important role in T cell development as well as in trafficking and activation of mature T cells. It functions as a selective chemo-attractant for T cells that express a class of receptors binding TARC with high affinity and specificity. TARC acts as a functional ligand for CCR4, and CCR4 that are specific receptor for TARC selectively expressed on T cells. In Hodgkin lymphoma (HL) disease it is highly expressed and is a possible biomarker in HL patients. TARC expression is resistant to corticosteroid and is suppressed by PI3K enzyme inhibitors.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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