Anti-phospho-α-B Crystallin (54-64) (pSer⁵⁹) antibody produced in rabbit

产品说明

一般描述

α-B-crystallin (CRYAB) belongs to small heat-shock protein family with chaperone-like function. Almost entire lens proteins composed of crystallins and within that α-crystallin accounts for 40% of total lens protein. α-Crystallin is composed of two primary gene products, α-A and α-B. α-B crystallin in particular, has been detected in many tissues in the central nervous system, and is considered to be a useful marker in a variety of neurodegenerative diseases.

特异性

This antibody does not detect the unphosphorylated form of the protein.

免疫原

synthetic phosphopeptide: FLRAPS(p)WIDTG

应用

Anti-phospho-α-B Crystallin (54-64) (pSer⁵⁹) antibody is suitable for indirect immunofluorescence in 8μg/mL using human brain from Alexander′s diseased patients. It is also suitable for western blot analysis in concentration of 0.5μg/mL using recombinant bovine phospho-α-B crystallin (Ser⁵⁹).

生化/生理作用

Anti-phospho-α-B Crystallin (54-64) (pSer⁵⁹) antibody is responsible for the optical properties of the lens and have been identified from metabolic enzymes and stress proteins. In many neurological diseases, α B-crystallin have found over-expressed and any alterations in this protein leads cataract and myopathy. In addition to maintaining proper refractive index, it also functions in a chaperone-like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of α-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance.

外形

Lyophilized from phosphate buffered saline, pH 7.4, with 3% bovine serum albumin and 0.05% sodium azide.

基本信息

产品性质