3α，12α-二羟基-5β-胆汁酸

产品名称：

83-44-3
Deoxycholic Acid
7-Deoxycholic acid
DESOXYCHOLIC ACID
3α,12α-Dihydroxy-5β-cholanic acid
脱氧胆酸
7-脱氧胆酸
3α，12α-二羟基-5β-胆汁酸

产品介绍：

产品说明

一般描述

Deoxycholic acid is an amphiphilic molecule and an important constituent of bile acid. It contains hydroxyl groups substituted at the 3α and 12α positions and a carboxyl group towards the end of the branched-chain. These moieties contribute to the hydrophilic nature of the molecule and the hydrophobic cyclopentanophenanthrene forms its center.

应用

Deoxycholic acid has been used as:

a hyphal-inhibitory compound in an ex vivo assay to study the hyphal morphogenesis of Candida albicans in the gastrointestinal tract
an internal standard to estimate the toxin concentration in the cell pellet
a bile acid (BA) standard to quantitatively measure BA in various samples from treated mice by ultra-performance liquid chromatography triple quadrupole mass spectrometry

生化/生理作用

Deoxycholic acid, due to its amphiphilicity, significantly helps to solubilize, emulsify, and absorb fat, vitamins, and cholesterol in the body. High levels of intestinal deoxycholic acid might cause colorectal cancer by inducing oxidative stress and leading to DNA damage. It acts as an oncogene and pro-tumor factor.

其他说明

用于β-肾上腺素能受体的增溶

基本信息

经验(实验)分子式	C₂₄H₄₀O₄
分子量	392.57
Beilstein	3219882
EC 号	201-478-5
MDL编号	MFCD00003673
PubChem化学物质编号	329753610
NACRES	NA.77

产品性质

质量水平	100
生物来源	ox bile
描述	anionic
测定	≥99.0% (T)
形式	powder
旋光性	[α]20/D +54±1°, c = 1% in ethanol
分子量	392.57 g/mol
杂质	≤1% cholic acid (TLC)
mp	170-175 ℃ 171-174 ℃ (lit.)
官能团	carboxylic acid
SMILES string	C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
InChI	1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1
InChI key	KXGVEGMKQFWNSR-LLQZFEROSA-N
Gene Information	human ... ATIC(471)

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P301 + P312 + P330
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves