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Fas Ligand human

品牌
Sigma-Aldrich
货号
F0427
规格纯度
>95% (SDS-PAGE), recombinant, expressed in CHO cells, lyophilized powder
参考价格
12590.3 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Fas Ligand human
FasL
产品介绍:

产品说明

一般描述

FASLG (Fas ligand) acts as a ligand for Fas receptor, and is a major protein involved in programmed cell death, apoptosis. Soluble Fas (sFAS) is usually detected in plasma prior to apoptosis.

应用

Fas Ligand (FASLG) human has been used for-

  • the study of FASLG stimulation in luteal cells obtained from mid-corpus luteum (CL) and
  • the study of apoptosis induction and intracellular caspase-3 assay in human cells.

生化/生理作用

Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).
FASLG (Fas ligand) and Fas receptor constitute the basic elements in apoptosis. Interaction of FASLG with Fas receptor leads to activation of caspase-8. This caspase in turn leads to activation of effector caspases such as caspase-3, -6 and -7. This cascade results in the hydrolysis of nuclear and cytoplasmic components. Expression of FASLG is induced by nuclear factor-κB (NFκB). NFκB/FASLG pathway facilitates the suppression of p,p′-DDT (dichlorodiphenoxytrichloroethane)-induced cell toxicity by vitamin C and E. In CD4+ T cells, this protein is expressed on stimulus by T-cell receptor (TCR), both during normal and pathological conditions, such as alcohol exposure.

其他说明

Human Fas Ligand, N-terminal 6X histidine-tagged, encodes amino acids 134-281.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

分析说明

Measured by its ability to induce apoptosis in Jurkat cells.

基本信息

MDL编号MFCD01092558
NACRESNA.32

产品性质

质量水平100
重组expressed in CHO cells
测定>95% (SDS-PAGE)
形式lyophilized powder
分子量monomer calculated mol wt ~18 kDa
26-28 kDa by SDS-PAGE
杂质 endotoxin, tested
UniProt登记号P48023
储存温度−20℃
Gene Informationhuman ... FASLG(356)

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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