Anti-Frizzled-10 antibody produced in rabbit

产品说明

免疫原

synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-10, conjugated to KLH. The immunizing peptide has 100% homology with the mouse gene.

应用

Anti-Frizzled-10 antibody is suitable for immunohistochemistry study (formalin-fixed, paraffin-embedded sections) at a concentration of 3μg/mL using human kidney, cortex.

生化/生理作用

Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In humans, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. FZD10, a cell-surface receptor molecules in the Wnt pathway, is expressed during development in embryonic limbs, neural tube, and central nervous system and mediates Wnt signaling. It was reported that FZD10 plays a critical role in the metastasis of synovial sarcoma. Mechanistically, it facilitates the activation of Dvl-Rac1-JNK axis of planar cell polarity (PCP) signaling, with no effect on nuclear β-catenin accumulation and Tcf/Lef reporter activity.

外形

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

基本信息

产品性质