产品说明
一般描述
Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is repoted to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodelling and angiogenesis. The role of bFGF in chondrocyte proliferation and repair has established the role of bFGF in maintaining cartilage and intervertebral disc homeostasis. Along with VEGF, bFGF is important in angiogenesis and tumorigenesis in response to inflammatory cytokines
Monoclonal Anti-Fibroblast Growth Factor Basic recognizes human Fibroblast Growth Factor Basic. It also recognizes bovine bFGF. It shows 0.2% cross-reactivity with bovine FGF acidic. It does not react with human FGF acidic, FGF-4, -6 or -7.
免疫原
purified, E. coli-derived recombinant human fibroblast growth factor basic.
应用
Monoclonal Anti-Fibroblast Growth Factor Basic may be used as capture antibody in ELISA at a recommended concentration range of 2-8 μg/ml.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
MDL编号 | MFCD00212948 |
NACRES | NA.41 |
产品性质
质量水平 | 100 |
生物来源 | mouse |
偶联物 | unconjugated |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | 10060, monoclonal |
形式 | lyophilized powder |
species reactivity | human |
technique(s) | capture ELISA: 2-8 μg/mL |
同位素/亚型 | IgG2a |
UniProt登记号 | P09038 |
储存温度 | −20℃ |
Gene Information | human ... FGF2(2247) |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich