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Milli-Mark® Anti-TrkA-FITC Antibody

品牌
Sigma-Aldrich
货号
FCABS350F
规格纯度
Milli-Mark®, from rabbit
参考价格
5016.79 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Milli-Mark® Anti-TrkA-FITC Antibody
Neurotrophic tyrosine kinase receptor type, Oncogene TRK, TRK1-transforming tyrosine kinase protein, high affinity nerve growth factor receptor, neurotrophic tyrosine kinase, receptor, type 1
产品介绍:

产品说明

一般描述

TrkA is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.

特异性

Unconjugated version Cat.No.06-574 is predicted to react with Rat based on immunogen design. The unconjugated part number was also shown to react with Mouse.
Antibody recognizes TrkA protein.

免疫原

Bacterially expressed purified protein corresponding to the entire extracellular domain of rat TrkA receptor.
Epitope: Extracellular domain

应用

Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases
Research Category
Neuroscience
Detect TrkA using this Milli-Mark Anti-TrkA-FITC Antibody validated for use in FC.

质量

Evaluated by flow cytometry using HeLa cells.

目标描述

TrkA exists as two isoforms: 87 kDa and 88 kDa

外形

Purified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Protein A purified

储存及稳定性

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

分析说明

Control
HeLa cells

法律信息

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物FITC conjugate
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆polyclonal
species reactivityhuman
manufacturer/tradenameMilli-Mark®
technique(s)flow cytometry: suitable
同位素/亚型IgG
NCBI登记号NP_067600
UniProt登记号P35739
运输wet ice

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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